猪繁殖与呼吸综合征病毒类NADC30毒株FJZ03的致病性分析

doi:10.11843/j.issn.0366-6964.2018.06.016

Abstract

Abstract:

The aim of this study was to explore the biological characteristics and pathogenic of a NADC30-like PRRSV. Thirty days old piglets confirmed to be free of PRRSV and PCV2 were inoculated with a NADC30-like PRRSV FJZ03 strain and a HP-PRRSV FJLYDX strain, respectively. The clinical symptoms, rectal temperature, virus excretion, virus loads in the sera, and tissues lesions were monitored and recorded. We found that FJZ03 strain could be rapidly replicated and developed higher titer of viremia in piglets. Moreover, the time of rectal temperatures rose and virus excretion in FJZ03 infected piglets were earlier than that of FJLYDX infected. Furthermore, piglets infected with FJZ03 displayed severe interstitial pneumonia and spleen atrophy. Cytokine test results showed that the cytokines concentrations of sera of FJZ03 infected piglets increased at different degrees. The IL-10 and TNF-α concentration in FJZ03 group was obvious higher than that of the FJLYDX group. Therefore, our results indicated that FJZ03 is pathogenic for piglets.

CLC Number:

S852.659.6

LIU Jian-kui, FAN Jia-lin, WEI Chun-hua, LI Yan, LIU Jia-yue, MA Lu-lu, YU Hui-yun, DAI Ai-ling, YANG Xiao-yan. Pathogenicity of a NADC30-like Strain FJZ03 of Porcine Reproductive and Respiratory Syndrome Virus Emerged in China[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(6): 1241-1248.

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Pathogenicity of a NADC30-like Strain FJZ03 of Porcine Reproductive and Respiratory Syndrome Virus Emerged in China

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